5/22/2025
Last update
5/22/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
Alendronate reduces pain and improves BMD
We explored the effectiveness of alendronate, a common drug for osteoporosis, in treating bone pain and improving bone health in patients with thalassemia. This randomized controlled trial involved men and premenopausal women, who were given either alendronate or a placebo for 12 months.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
Read More
8
We examined a case of a 32-year-old woman on long-term hemodialysis who experienced severe bone pain and fractures. Initial tests showed high levels of iron and aluminum. After treating her with deferoxamine—a chelating agent—her bone pain improved, and a follow-up biopsy showed better bone health. However, while her pain was managed, her iron and aluminum levels changed only slightly, highlighting the complexity of treating conditions linked to metal imbalances.
Read More
8
We explored how cancer in the bones, specifically from breast tumors, leads to severe pain due to increased levels of glutamate. In our research, we found that certain chemicals, including iron-based compounds, can reduce this glutamate release. This reduction helps alleviate pain symptoms in models of cancer-induced bone pain. While our findings suggest that targeting the glutamate pathway may be effective, we did not find that iron treatment alone significantly impacts bone pain management. Overall, this study highlights potential new avenues for treating pain associated with bone metastases.
Read More
Most Useful Reviews
9
Improved wellbeing
46 people found this helpful
I'm amazed by the results of this iron supplement! After struggling with low haemoglobin, my doctor recommended it. I opted for a chelative iron that is gentle on the stomach. After a month, my levels rose significantly, and I felt energised without experiencing any bone pain or other side effects. I highly recommend it!
Read More
9
Hair growth improvement
23 people found this helpful
This iron supplement has been terrific for me. I had no issues with my stomach, and after three months, I noticed not only improvement in my iron levels but also in my hair growth, and any related bone pain during menstruation became almost non-existent.
Read More
9
Consistent haemoglobin
2 people found this helpful
This iron supplement has been fantastic during my pregnancy, helping to maintain my haemoglobin levels without causing any bone pain. I felt great while taking it, even increasing the dosage towards the end.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
- All Researches
9
Alendronate reduces pain and improves BMD
We explored the effectiveness of alendronate, a common drug for osteoporosis, in treating bone pain and improving bone health in patients with thalassemia. This randomized controlled trial involved men and premenopausal women, who were given either alendronate or a placebo for 12 months.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
Read More
8
We explored how cancer in the bones, specifically from breast tumors, leads to severe pain due to increased levels of glutamate. In our research, we found that certain chemicals, including iron-based compounds, can reduce this glutamate release. This reduction helps alleviate pain symptoms in models of cancer-induced bone pain. While our findings suggest that targeting the glutamate pathway may be effective, we did not find that iron treatment alone significantly impacts bone pain management. Overall, this study highlights potential new avenues for treating pain associated with bone metastases.
Read More
8
We examined a case of a 32-year-old woman on long-term hemodialysis who experienced severe bone pain and fractures. Initial tests showed high levels of iron and aluminum. After treating her with deferoxamine—a chelating agent—her bone pain improved, and a follow-up biopsy showed better bone health. However, while her pain was managed, her iron and aluminum levels changed only slightly, highlighting the complexity of treating conditions linked to metal imbalances.
Read More
7
We examined the long-term safety and effectiveness of luspatercept in adult patients with β-thalassemia, a genetic blood disorder that leads to anemia. The study involved a diverse group of 64 patients, analyzing how well luspatercept could help increase hemoglobin levels and reduce blood transfusions over an extended period.
Importantly, while luspatercept showed significant benefits, common side effects included mild headaches and bone pain. However, these symptoms did not emerge as major concerns, and patients reported manageable experiences overall.
Our findings suggest luspatercept can be a valuable treatment for both transfusion-dependent and nontransfusion-dependent β-thalassemia patients.
Importantly, while luspatercept showed significant benefits, common side effects included mild headaches and bone pain. However, these symptoms did not emerge as major concerns, and patients reported manageable experiences overall.
Our findings suggest luspatercept can be a valuable treatment for both transfusion-dependent and nontransfusion-dependent β-thalassemia patients.
Read More
7
We explored the connection between bone pain and iron treatment in patients on maintenance hemodialysis. In our observation, two patients suffered from bone pain related to aluminum and iron-related bone disease, which was alleviated by deferoxamine therapy.
However, we also noted that three patients experienced transverse fractures under normal daily activities. This indicates that both aluminum and iron-related diseases can weaken bone, leading to fractures even with minimal stress.
However, we also noted that three patients experienced transverse fractures under normal daily activities. This indicates that both aluminum and iron-related diseases can weaken bone, leading to fractures even with minimal stress.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved wellbeing
46 people found this helpful
I'm amazed by the results of this iron supplement! After struggling with low haemoglobin, my doctor recommended it. I opted for a chelative iron that is gentle on the stomach. After a month, my levels rose significantly, and I felt energised without experiencing any bone pain or other side effects. I highly recommend it!
Read More
9
Hair growth improvement
23 people found this helpful
This iron supplement has been terrific for me. I had no issues with my stomach, and after three months, I noticed not only improvement in my iron levels but also in my hair growth, and any related bone pain during menstruation became almost non-existent.
Read More
9
Consistent haemoglobin
2 people found this helpful
This iron supplement has been fantastic during my pregnancy, helping to maintain my haemoglobin levels without causing any bone pain. I felt great while taking it, even increasing the dosage towards the end.
Read More
9
Skin improvement
2 people found this helpful
I've taken this iron supplement for under a month, and I've already noticed major improvements. My skin feels better, I've achieved relief from bone pain during menstruation, and I have more energy!
Read More
9
Eased bone pain
1 people found this helpful
By the end of my first jar, I noticed significant improvements: my inflamed nerve pain diminished, allowing me to sleep without painkillers, and the pulling sensation in my lower back before menstruation has gone. I've even felt relief from constant breathlessness. I ordered another jar.
Read More
Frequently Asked Questions
9
Skin improvement
2 people found this helpful
I've taken this iron supplement for under a month, and I've already noticed major improvements. My skin feels better, I've achieved relief from bone pain during menstruation, and I have more energy!
9
Improved wellbeing
46 people found this helpful
I'm amazed by the results of this iron supplement! After struggling with low haemoglobin, my doctor recommended it. I opted for a chelative iron that is gentle on the stomach. After a month, my levels rose significantly, and I felt energised without experiencing any bone pain or other side effects. I highly recommend it!
9
Hair growth improvement
23 people found this helpful
This iron supplement has been terrific for me. I had no issues with my stomach, and after three months, I noticed not only improvement in my iron levels but also in my hair growth, and any related bone pain during menstruation became almost non-existent.
9
Healed bone pain
1 people found this helpful
I discovered this supplement a year ago during a severe episode of anaemia with intense bone pain. It revitalised me and alleviated the aching in my feet. After taking it consistently for six months, followed by a break, I resumed and found it beneficial for both me and my daughter.
6
Joint stiffness relief
3 people found this helpful
After feeling stiffness and pain in my joints, I suspected iron deficiency. I started taking chelated iron with vitamins, and my bone pain is nearly gone now. Although I initially faced concerns about chelated iron, I’ve had no problems and feel much better.
9
No more bone pain
1 people found this helpful
My spouse started taking this supplement before and during her periods, and she noticed improvements from the first year. By the third month, her menstrual pain had ceased, leaving her feeling light and content. It’s certainly effective for her!
0
Severe nausea
8 people found this helpful
I began taking these pills to raise my ferritin, which was at the lower limit. Initially, after a week, I felt nauseous at night and in the morning, followed by constipation and intestinal pain. Since I was taking vitamins separately, I stopped all medications and reintroduced them individually. This drug was added last, but I experienced nausea and constipation again. Therefore, I cannot recommend this medication due to its adverse effects.
0
High dosage issues
The dosage was too high for me. After my first dose, I suffered severe intestinal pain and constipation, which are typical symptoms of iron overdose. This experience has made me hesitant to try other supplements.
9
Alendronate reduces pain and improves BMD
We explored the effectiveness of alendronate, a common drug for osteoporosis, in treating bone pain and improving bone health in patients with thalassemia. This randomized controlled trial involved men and premenopausal women, who were given either alendronate or a placebo for 12 months.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
5
We reviewed various treatments for osteoporosis in individuals with beta-thalassemia to see how they alleviate bone pain. Among the treatments, bisphosphonates showed potential for increasing bone density, while zinc supplementation was likely to enhance site-specific bone mass.
Notably, denosumab and strontium ranelate appeared to significantly reduce bone pain measured on a scale, indicating improved quality of life. However, the overall evidence certainty was low, emphasizing a need for more extensive trials. There's promise, but further research is essential to draw firmer conclusions.
Notably, denosumab and strontium ranelate appeared to significantly reduce bone pain measured on a scale, indicating improved quality of life. However, the overall evidence certainty was low, emphasizing a need for more extensive trials. There's promise, but further research is essential to draw firmer conclusions.
8
We examined a case of a 32-year-old woman on long-term hemodialysis who experienced severe bone pain and fractures. Initial tests showed high levels of iron and aluminum. After treating her with deferoxamine—a chelating agent—her bone pain improved, and a follow-up biopsy showed better bone health. However, while her pain was managed, her iron and aluminum levels changed only slightly, highlighting the complexity of treating conditions linked to metal imbalances.
7
We explored the connection between bone pain and iron treatment in patients on maintenance hemodialysis. In our observation, two patients suffered from bone pain related to aluminum and iron-related bone disease, which was alleviated by deferoxamine therapy.
However, we also noted that three patients experienced transverse fractures under normal daily activities. This indicates that both aluminum and iron-related diseases can weaken bone, leading to fractures even with minimal stress.
However, we also noted that three patients experienced transverse fractures under normal daily activities. This indicates that both aluminum and iron-related diseases can weaken bone, leading to fractures even with minimal stress.
8
We explored how cancer in the bones, specifically from breast tumors, leads to severe pain due to increased levels of glutamate. In our research, we found that certain chemicals, including iron-based compounds, can reduce this glutamate release. This reduction helps alleviate pain symptoms in models of cancer-induced bone pain. While our findings suggest that targeting the glutamate pathway may be effective, we did not find that iron treatment alone significantly impacts bone pain management. Overall, this study highlights potential new avenues for treating pain associated with bone metastases.
References
- Piriyakhuntorn P, Tantiworawit A, Phimphilai M, Srichairatanakool S, Teeyasoontranon W, et al. The efficacy of alendronate for the treatment of thalassemia-associated osteoporosis: a randomized controlled trial. Front Endocrinol (Lausanne). 2023;14:1178761. 10.3389/fendo.2023.1178761
- Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. 10.1002/14651858.CD010429.pub3
- Piga A, Longo F, Gamberini MR, Voskaridou E, Ricchi P, et al. Long-term safety and erythroid response with luspatercept treatment in patients with β-thalassemia. Ther Adv Hematol. 2022;13:20406207221134404. 10.1177/20406207221134404
- Slosky LM, BassiriRad NM, Symons AM, Thompson M, Doyle T, et al. The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain. Pain. 2016;157:2605. 10.1097/j.pain.0000000000000681
- Yamagata K, Kobayashi M, Koyama A, Narita M, Amagai H, et al. [A case of iron and aluminum related osteomalacia in a long-term hemodialysis patient]. Nihon Jinzo Gakkai Shi. 1991;33:437.
- Marumo F, Nomura T, Nishikawa H. Transverse fractures of the spinous process of the 7th cervical vertebra in RDT patients: an Al related disease?. Int J Artif Organs. 1987;10:93.
